RUP News

Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration.

Faculty of 1000 -- This elegant study unveils new and important mechanistic details about the regulation of integrin traffic by the small GTPase Rab21 (more)

Doença de Chagas pega 'carona' em lesão celular

veja.com -- O protozoário Trypanosoma cruzi, causador da doença de Chagas, aproveita um mecanismo próprio de reparo da membrana da célula hospedeira para invadi-la (more)

Finnish find throws new light on cancer

YLE News -- Researchers... have found a new type of mechanism in cancer cells preventing the spread and growth of cancer (more)

B cells: The B boyz of sepsis

Nature Reviews Immunology -- Moldawer and colleagues show that type I interferon (IFN)-activated B cells can also contribute to acute inflammation during caecal ligation and puncture (CLP)-induced sepsis (more)

T cells: A metabolic sHIFt to turn 17

Nature Reviews Immunology -- A new study shows that... (HIF1α) is required for the metabolic changes that occur in differentiating T helper 17 (T_H17) cells (more)

Mutant Huntingtin(Htt) Activates AMPK-α1 in Mice, Humans

Doctors Lounge -- The mutant huntingtin(Htt) (mHtt) gene activates the α1 isoform of... (AMPK) in the striatal neurons of humans and mice with Huntington's disease (more)

In Brief: Development

Nature Reviews Molecular Cell Biology -- Lander et al. injected Twist mRNA into early Xenopus laevis embryos and concluded that, as Twist protein levels decreased during neural crest development (more)

Wie Retinoidsäure Nervenzellen wachsen lässt

Deutsches Ärzteblatt -- Einen bisher unbekannten molekularen Mechanismus, der für die Wirkung der Retinoidsäure verantwortlich ist (more)

Transient binding of an activator BH3 domain

Faculty of 1000 -- This paper provides elegant proof that a BH3-only protein (Noxa) can directly activate the pro-apoptotic molecule Bak (more)

An inflammatory turn-off

Nature Immunology -- Cohen et al. report the generation of mice that express mutant ABIN molecules which are defective in the ability to bind K63-polyubiquitin chains (more)