RUP News

Detailed picture of how myoV 'walks' along actin tracks

Science Codex -- A new study in the Journal of General Physiology uses state-of-the-art fluorescence microscopy to provide a striking 3-D picture of how class V myosins "walk" along their actin track (more)

Nuevas dianas terapéuticas contra la distrofia muscular

levante.emv.com -- Un equipo... ha descrito cómo el aumento de la producción de un microARN promueve el deterioro muscular progresivo en un modelo de ratón de distrofia muscular de Duchenne (more)

Breakthrough treatment could fight both leukemia and breast cancer

io9 -- Two papers published this week in the Journal of Experimental Medicine examine the protein HSP90, which plays a role in the growth of tumors (more)

Descoberta molécula para atacar doenças como Alzheimer ou cancro

Jornal de Notícias -- A investigação da Universidade do Minho liderada por Sandra Paiva foi publicada este mês na conceituada revista "Journal of Cell Biology" (more)

p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

Faculty of 1000 -- This work... provides convincing new evidence that both p38 and... (MKP-1) in leukocytes can play a role in modulating regeneration of injured muscle (more)

PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy

Faculty of 1000 -- This was an exciting paper to read that provided useful in vitro and in vivo genetic information to better understand the mechanisms underlying fibrosis in muscular dystrophy (more)

Viral immunity: Lose TRAF1, lose control

Nature Reviews Immunology -- Recent research describes a new defect that is associated with CD8⁺ T cell dysfunction in chronic viral infection (more)

Cancer Cell Death by Starvation

dailyRx -- Researchers were able to shrink tumors in mice when they blocked a protein that helps cancer cells grow where oxygen doesn't like to go (more)

Targeting One Protein May Fight Several Cancers

Insidermedicine -- Two reports published in the Journal of Experimental Medicine find a single protein that may be key to fighting several forms of cancer (more)

Post-translational modification: A monoubiquitylation pore anchor

Nature Reviews Molecular Cell Biology -- Dargemont and colleagues reveal that much of the [nuclear pore complex] can be ubiquitylated and, in the case of yeast Nup159, this is crucial for normal cell division (more)